All Publications

Christoph Schürmann, Franziska Dienst, Katalin Pálfi, Andrea E. Vasconez, James A. Oo, Sheng Peng Wang, Giulia K. Buchmann, Stefan Offermanns, Bart van de Sluis, Matthias S. Leisegang, Stefan Günther, Patrick O. Humbert, Eunjee Lee, Jun Zhu, Andreas Weigert, Praveen Mathoor, Ilka Wittig, Christoph Kruse, Ralf Brandes

The polarity protein Scrib limits atherosclerosis development in mice

2019, Cardiovascular Research

Jörn Lötsch, Thomas Hummel

A machine-learned analysis suggests non-redundant diagnostic information in olfactory subtests.

2019, IBRO Reports

Jörn Lötsch, Dario Kringel, Thomas Hummel

Machine Learning in Human Olfactory Research

2019, Chemical Sensesl

Iris Weyer-Menkhoff, Jörn Lötsch

TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers.

2019, The Clinical Journal of Pain

Sorwe Mojtahed Poor, Thomas Ulshöfer, Laureen Gabriel, Marina Henke, Michaela Köhm, Frank Behrens, Gerd Geisslinger, Michael J. Parnham, Harald Burkhardt, Susanne Schiffmann

Immunogenicity assay development and validation for biologic therapy as exemplified by ustekinumab

2019, Clinical & Experimental Immunology

Anna Kraus, Marissa Penna-Martinez, Firouzeh Shoghi, Christian Seidl, Gesine Meyer, Klaus Badenhoop

HLA-DQB1 pos. 57 defines susceptibility to isolated and polyglandular autoimmunity in adults: interaction with gender.

2018, The Journal of Clinical Endocrinology and Metabolism

Catharina Lippmann, Alfred Ultsch, Jörn Lötsch

Computational functional genomics-based reduction of disease-related gene sets to their key components

2018, Bioinformatics

Neda Tarighi, Dominic Menger, Sandra Pierre, Lisa Kornstädt, Dominique Thomas, Nerea Ferreiros, Rolf Nüsing, Gerd Geisslinger, Klaus Scholich

Thromboxane-induced α-CGRP release from peripheral neurons is an essential positive feedback loop in capsaicin-induced neurogenic inflammation.

2018, Journal of Investigative Dermatology

Iris Weyer-Menkhoff, Michael Thrun, Jörn Lötsch

Machine-learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects

2018, European Journal of Pain

Iris Weyer-Menkhoff, Jörn Lötsch

Human pharmacological approaches to TRP-ion-channel-based analgesic drug development

2018, Drug Discovery Today

Elsa-Marie Treutlein, Katharina Kern, Andreas Weigert, Neda Tarighi, Claus-Dieter Schuh, Rolf Nüsing, Yannick Schreiber, Nerea Ferreiros, Bernhard Brüne, Gerd Geisslinger, Sandra Pierre, Klaus Scholich

The prostaglandin E2 receptor EP3 controls CC-chemokine ligand 2-mediated neuropathic pain induced by mechanical nerve damage

2018, The Journal of Biological Chemistry

Saravanabalaji Shanmugam, Alyssa K. Nichols, Dhanaranjani Saravanabalaji, Christian Welsch, MinKyung Yi

HCV NS5A dimer interface residues regulate HCV replication by controlling its self-interaction, hyperphosphorylation, subcellular localization and interaction with cyclophilin A.

2018, PLOS Pathogens

Simone Schierle, Cathrin Flauaus, Pascal Heitel, Sabine Willems, Jurema Schmidt, Astrid Kaiser, Lilia Weizel, Tamara Göbel, Astrid Stefanie Kahnt, Gerd Geisslinger, Dieter Steinhilber, Mario Wurglics, G. Enrico Rovati, Achim Schmidtko, Eugen Proschak, Daniel Merk

Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology

2018, Journal of Medicinal Chemistry

Sandra Pierre, Dong-Dong Zhang, Jing Suo, Katharina Kern, Neda Tarighi, Klaus Scholich

Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice

2018, European Journal of Immunology

Jörn Lötsch, Iris Weyer-Menkhoff, Irmgard Tegeder

Current evidence of cannabinoid-based analgesia obtained in preclinical and human experimental settings

2018, European Journal of Pain

Daniel Glatzel, Andreas Koeberle, Helmut Pein, Konstantin Löser, Anna Stark, Nelli Keksel, Oliver Werz, Rolf Müller, Iris Bischoff, Robert Fürst

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition

2018, The Journal of Lipid Research

Leonard Blum, Nadja Tafferner, Ilknur Spring, Jennifer Kurz, Natasja de Bruin, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Dietary phytol reduces clinical symptoms in experimental autoimmune encephalomyelitis (EAE) at least partially by modulating NOX2 expression.

2018, Journal of Molecular Medicine

Leonard Blum, Susanne Schiffmann, Michael J. Parnham

Immunomodulation by antibiotics

2018, Fighting Antimicrobial Resistance (IAPC Book)

Andrea E. Vasconez, Patrick Janetzko, James A. Oo, Beatrice Pflüger-Müller, Corina Ratiu, Lunda Gu, Kristian Helin, Gerd Geisslinger, Ingrid Fleming, Katrin Schröder, Christian Fork, Ralf Brandes, Matthias S. Leisegang

The histone demethylase Jarid1b mediates angiotensin II-induced endothelial dysfunction by controlling the 3'UTR of soluble epoxide hydrolase

2018, Acta Physiologica

Michael Rühl, Benjamin Kühn, Jessica Roos, Thorsten Maier, Dieter Steinhilber, Michael Karas

Elucidation of chemical modifier reactivity towards peptides and proteins and the analysis of specific fragmentation by MALDI‐CID‐MS2.

2018, Rapid Communications in Mass Spectrometry

Benjamin Kühn, Camilla Brat, Jasmin Fettel, Nadine Hellmuth, Isabelle Maucher, Ufuk Bulut, Katharina J. Hock, Jennifer Grimmer, Georg Manolikakes, Michael Rühl, Alessa Kühn, Kai Zacharowski, Carmela Matrone, Anja Urbschat, Jessica Roos, Dieter Steinhilber, Thorsten Maier

Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells.

2018, Biochemical Pharmacology

Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Nadja Wallner, Gerd Geisslinger, Andreas Weigert, Michael J. Parnham

An in vitro test system for compounds that modulate human inflammatory macrophage polarization

2018, European Journal of Pharmacology

Catharina Lippmann, Dario Kringel, Alfred Ultsch, Jörn Lötsch

Computational functional genomics-based approaches in analgesic drug discovery and repurposing

2018, Pharmacogenomics

Julius C. Enßle, Cathinka Boedicker, Marek Wanior, Meike Vogler, Stefan Knapp, Simone Fulda

Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells

2018, Cancer Letters

Sandra Pierre, Dong-Dong Zhang, Jing Suo, Katharina Kern, Neda Tarighi, Klaus Scholich

Myc binding protein 2 suppresses M2-like phenotypes in macrophages during zymosan-induced inflammation in mice

2018, European Journal of Immunology

Marthe-Susanna Wegner, Nina Schömel, Lisa Gruber, Stephanie Beatrice Örtel, Matti Aleski Kjellberg, Peter Mattjus, Jennifer Kurz, Sandra Trautmann, Bing Peng, Martin Wegner, Manuel Kaulich, Robert Ahrends, Gerd Geisslinger, Sabine Grösch

UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells

2018, Cellular and Molecular Life Sciences

Andreas Weigert, Andreas von Knethen, Dominik Fuhrmann, Nathalie Dehne, Bernhard Brüne

Redox-signals and macrophage biology (for the upcoming issue of molecular aspects of medicine on signaling by reactive oxygen species)

2018, Molecular Aspects of Medicine

Franziska Moll, Maria Walter, Flávia Rezende, Valeska Helfinger, Andrea E. Vasconez, Tiago De Oliveira, Florian R. Greten, Catherine Olesch, Andreas Weigert, Heinfried H. Radeke, Katrin Schröder

NoxO1 Controls Proliferation of Colon Epithelial Cells

2018, Frontiers in Immunology

Mark Wroblewski, Marina Scheller-Wendorff, Florian Udonta, Raimund Bauer, Jara Schlichting, Lin Zhao, Isabel Ben Batalla, Victoria Gensch, Sarina Präsler, Lei Wu, Marek Wanior, Hanna Taipaleenmäki, Simona Bolamperti, Zeynab Najafova, Klaus Pantel, Carsten Bokenmeyer, Jun Qi, Eric Hesse, Stefan Knapp, Steven Johnsen, Sonja Loges

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

2018, Haematologica

Ivana Josipovic Josipovic, Beatrice Pflüger-Müller, Christian Fork, Andrea E. Vasconez, James A. Oo, Juliane Hitzel, Sandra Seredinski, Elisabetta Gamen, Dagmar Meyer zu Heringdorf, Wei Chen, Mario Looso, Soni S. Pullamsetti, Ralf Brandes, Matthias S. Leisegang

Long noncoding RNA LISPR1 is required for S1P signaling and endothelial cell function

2018, Journal of Molecular and Cellular Cardiology

Christian Fork, Andrea E. Vasconez, Patrick Janetzko, Carlo Angioni, Yannick Schreiber, Nerea Ferreiros, Matthias S. Leisegang, Gerd Geisslinger, Dieter Steinhilber, Ralf Brandes

Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300

2017, The Journal of Lipid Research

Sandra Vomund, Anne Schäfer, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Nrf2, the Master Regulator of Anti-Oxidative Responses

2017, International Journal of Molecular Sciences

Leonie Stolz, Amin Derouiche, Kavi Devraj, Frank Weber, Robert Brunkhorst, Christian Förch

Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis

2017, Journal of Neuroinflammation

Katrin Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian Ottenlinger, Dominique Thomas, Frank Zaucke, Josef Pfeilschifter, Heinfried H. Radeke

Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study

2017, Frontiers in Immunology

Jessica Roos, Marcus Peters, Isabelle Maucher, Benjamin Kühn, Jasmin Fettel, Nadine Hellmuth, Camilla Brat, Benita Sommer, Anja Urbschat, Matthias Piesche, Anja Vogel, Eugen Proschak, Rene Blöcher, Estel la Buscato, Ann-Kathrin Häfner, Carmela Matrone, Oliver Werz, Juliana Heidler, Ilka Wittig, Carlo Angioni, Gerd Geisslinger, Michael J. Parnham, Kai Zacharowski, Dieter Steinhilber, Thorsten Maier

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy

2017, Antioxidants & Redox Signaling

Katharina Kern, Sandra Pierre, Yannick Schreiber, Carlo Angioni, Dominique Thomas, Nerea Ferreiros, Gerd Geisslinger, Klaus Scholich

CD200 selectively upregulates prostaglandin E2 and D2 synthesis in LPS-treated bone marrow-derived macrophages

2017, Prostaglandins & Other Lipid Mediators

Daniel Flesch, Sun-Yee Cheung, Jurema Schmidt, Matthias Gabler, Pascal Heitel, Jan Kramer, Astrid Kaiser, Markus Hartmann, Mara Lindner, Kerstin Lüddens-Dämgen, Jan Heering, Christina Lamers, Hartmut Lüddens, Mario Wurglics, Eugen Proschak, Manfred Schubert-Zsilavecz, Daniel Merk

Nonacidic Farnesoid X Receptor Modulators

2017, Journal of Medicinal Chemistry

Anna Kraus, Marissa Penna-Martinez, Gesine Meyer, Klaus Badenhoop

Vitamin D effects on monocytes' CCL-2, IL6 and CD14 transcription in Addison's disease and HLA susceptibility

2017, The Journal of Steroid Biochemistry and Molecular Biology

Michaela Jung, Andreas Weigert, Christina Mertens, Claudia Rehwald, Bernhard Brüne

Iron Handling in Tumor-Associated Macrophages-Is There a New Role for Lipocalin-2

2017, Frontiers in Immunology

Catherine Olesch, Christian Ringel, Bernhard Brüne, Andreas Weigert

Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation

2017, Mediators of Inflammation

Erina Kakumu, Seiya Nakanishi, Hiromi Shiratori, Akari Kato, Wataru Kobayashi, Shinichi Machida, Takeshi Yasuda, Naoko Adachi, Naoaki Saito, Tsuyoshi Ikura, Hitoshi Kurumizaka, Hiroshi Kimura, Masayuki Yokoi, Wataru Sakai, Kaoru Sugasawa

Xeroderma pigmentosum group C protein interacts with histones: regulation by acetylated states of histone H3

2017, Genes to Cells

Hiromi Shiratori, Carmen Feinweber, Sonja Luckhardt, Bona Linke, Eduard Resch, Gerd Geisslinger, Andreas Weigert, Michael J. Parnham

THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro

2017, Molecular Immunology

Michaela Jung, Christina Mertens, Rebekka Bauer, Claudia Rehwald, Bernhard Brüne

Lipocalin-2 and iron trafficking in the tumor microenvironment

2017, Pharmacological Research

Jörn Lötsch, Catharina Lippmann, Dario Kringel, Alfred Ultsch

Integrated Computational Analysis of Genes Associated with Human Hereditary Insensitivity to Pain. A Drug Repurposing Perspective

2017, Frontiers in Molecular Neuroscience

Violeta Dimova, Bruno Oertel, Jörn Lötsch

Using a Standardized Clinical Quantitative Sensory Testing Battery to Judge the Clinical Relevance of Sensory Differences Between Adjacent Body Areas

2017, The Clinical Journal of Pain

Katrin Olbrich, Lara Costard, Christine V. Möser, Katharina Syhr, Tanya S King-Himmelreich, Miriam C. Wolters, Achim Schmidtko, Gerd Geisslinger, Ellen Niederberger

Cleavage of SNAP-25 ameliorates cancer pain in a mouse model of melanoma

2017, European Journal of Pain

Tanya S King-Himmelreich, Christine V. Möser, Miriam C. Wolters, Julia Schmetzer, Moritz Möller, Yannick Schreiber, Nerea Ferreiros, Gerd Geisslinger, Ellen Niederberger

[EXPRESS] AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice

2017, Molecular Pain

Tanya S King-Himmelreich, Christine V. Möser, Miriam C. Wolters, Julia Schmetzer, Yannick Schreiber, Nerea Ferreiros, Otto Quintus Russe, Gerd Geisslinger, Ellen Niederberger

AMPK contributes to aerobic exercise-induced antinociception downstream of endocannabinoids

2017, Neuropharmacology

Stephanie Beatrice Örtel, Klaus Scholich, Andreas Weigert, Dominique Thomas, Julia Schmetzer, Sandra Trautmann, Marthe-Susanna Wegner, Heinfried H. Radeke, Natalie Filman, Bernhard Brüne, Gerd Geisslinger, Irmgard Tegeder, Sabine Grösch

Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity

2017, Cellular and Molecular Life Sciences

Tatjana Scholz, Andreas Weigert, Bernhard Brüne, Christian D. Sadik, Beate Böhm, Harald Burkhardt

GM-CSF in murine psoriasiform dermatitis: Redundant and pathogenic roles uncovered by antibody-induced neutralization and genetic deficiency

2017, PLoS One

Laura Kuchler, Lisa Sha, Annika K Giegerich, Tilo Knape, Carlo Angioni, Nerea Ferreiros, Martina V. Schmidt, Andreas Weigert, Bernhard Brüne, Andreas von Knethen

Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis

2017, Molecular Immunology

Marissa Penna-Martinez, Klaus Badenhoop

Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition

2017, Molecular Diversity Preservation International

Eugen Proschak, Pascal Heitel, Lena Kalinowsky, Daniel Merk

Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.

2017, Journal of Medicinal Chemistry

Sebastian Zinn, Marco Sisignano, Katharina Kern, Sandra Pierre, Sorin Tunaru, Holger Jordan, Jing Suo, Elsa-Marie Treutlein, Carlo Angioni, Nerea Ferreiros, Andreas Leffler, Natasja de Bruin, Stefan Offermanns, Gerd Geisslinger, Klaus Scholich

The leukotriene B4 receptors BLT1 and BLT2 form an antagonistic sensitizing system in peripheral sensory neurons

2017, Journal Of Biological Chemistry

Katharina J. Hock, Jennifer Grimmer, Dominik Göbel, George Gichogo T. Gasaya, Isabelle Maucher, Benjamin Kühn, Jasmin Fettel, Thorsten Maier, Georg Manolikakes

Modular Regiospecific Synthesis of Nitrated Fatty Acids

2017, Synthesis

Pascal Heitel, Janosch Achenbach, Daniel Moser, Eugen Proschak, Daniel Merk

DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

2017, Bioorganic & Medicinal Chemistry Letters

Elsa-Marie Treutlein, Sebastian Zinn, Klaus Scholich

NSAR in the light of fever, inflammation and pain

2017, Pharmakon

Dimitra Bogdanou, Marissa Penna-Martinez, Natalie Filman, Tje Lin Chung, Yasmin Moran-Auth, Claudia Cappel, Sabine Huenecke, Eva Herrmann, Ulrike Köhl, Klaus Badenhoop

T-lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover

2016, Diabetes/metabolism research and reviews

Yasmin Moran-Auth, Marissa Penna-Martinez, D. Perner, S. Susser, Sabine Wicker, Stefan Zeuzem, C. Sarrazin, Klaus Badenhoop

IL28B gene variants and glucose metabolism in Type 2 Diabetes.

2016, Human Immunology

Hiromi Shiratori, Carmen Feinweber, Claudia Knothe, Jörn Lötsch, Dominique Thomas, Gerd Geisslinger, Michael J. Parnham, Eduard Resch

High-Throughput Analysis of Global DNA Methylation Using Methyl-Sensitive Digestion

2016, PloS one

Marco Sisignano, Carlo Angioni, Chul-Kyu Park, Sascha Meyer Dos Santos, Holger Jordan, Maria Kuzikov, Di Liu, Sebastian Zinn, Stephan Hohmann, Yannick Schreiber, Béla Zimmer, Mike Schmidt, Ruirui Lu, Jing Suo, Dong-Dong Zhang, Stephan M. G. Schäfer, Martine Hofmann, Ajay S. Yekkirala, Natasja de Bruin, Michael J. Parnham, Clifford J. Woolf, Ru-Rong Ji, Klaus Scholich, Gerd Geisslinger

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

2016, Proceedings of the National Academy of Sciences

Sandra K Wittmann, Lena Kalinowsky, Jan Kramer, Rene Blöcher, Stefan Knapp, Dieter Steinhilber, Denys Pogoryelov, Eugen Proschak, Jan Heering

Thermodynamic properties of leukotriene A4 hydrolase inhibitors

2016, Bioorganic & medicinal chemistry

Katja Zschiebsch, Caroline Fischer, Geethanjali Pickert, Annett Haussler, Heinfried H. Radeke, Sabine Grösch, Nerea Ferreiros, Gerd Geisslinger, Ernst Werner, Irmgard Tegeder

Tetrahydrobiopterin Attenuates DSS-evoked Colitis in Mice by Rebalancing Redox and Lipid Signalling

2016, Journal of Crohn's & colitis

Katharina Syhr, Sebastian Zinn, Gerd Geisslinger

Arzneimittelinteraktionen – „App” to date

2016, Aktuelle Neurologie

Marco Brenneis, Ramin Aghajaanpour, Tilo Knape, Lisa Sha, Holger Neb, Patrick Meybohm, Kai Zacharowski, Ingeborg Hauser, Stefan Büttner, Michael J. Parnham, Bernhard Brüne, Andreas von Knethen

Pparγ Expression in T Cells as a Prognostic Marker of Sepsis

2016, Shock

Tanya S King-Himmelreich, Stefanie Schramm, Miriam C. Wolters, Julia Schmetzer, Christine V. Möser, Claudia Knothe, Eduard Resch, Johannes Peil, Gerd Geisslinger, Ellen Niederberger

The impact of endurance exercise on global and AMPK gene-specific DNA methylation

2016, Biochemical and biophysical research communications

Claudia Knothe, Hiromi Shiratori, Eduard Resch, Alfred Ultsch, Gerd Geisslinger, Alexandra Doehring, Jörn Lötsch

Disagreement between two common biomarkers of global DNA methylation

2016, Clinical Epigenetics Society

Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Haussler, Boris Albuquerque, Béla Zimmer, Christine V. Möser, Frank Behrens, Frank Koentgen, Ilka Wittig, Mirko H. H. Schmidt, Albrecht M. Clement, Thomas Deller, Irmgard Tegeder

Progranulin overexpression in sensory neurons attenuates neuropathic pain in mice: Role of autophagy

2016, Neurobiology of Disease

Ivana Josipovic Josipovic, Christian Fork, Jens Preussner, Kim-Kristin Prior, Dijana Iloska, Andrea E. Vasconez, Sandra Labocha, Carlo Angioni, Dominique Thomas, Nerea Ferreiros, Mario Looso, Soni S. Pullamsetti, Gerd Geisslinger, Dieter Steinhilber, Ralf Brandes, Matthias S. Leisegang

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells

2016, Acta Physiologica

Susanne Beyer, Li Xie, Mike Schmidt, Natasja de Bruin, Mukul Ashtikar, Sabrina Ruschenbaum, Christian Lange, Vitali Vogel, Werner Mantele, Michael J. Parnham, Matthias G. Wacker

Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques

2016, Journal of Controlled Release

Karin Meirer, Daniel Glatzel, Simon Kretschmer, Sandra K Wittmann, Markus Hartmann, Rene Blöcher, Carlo Angioni, Gerd Geisslinger, Dieter Steinhilber, Bettina Hofmann, Robert Fürst, Eugen Proschak

Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

2016, Molecules

Marcel Boss, Yvette Newbatt, Sahil Gupta, Ian Collins, Bernhard Brüne, Dmitry Namgaladze

AMPK-independent inhibition of human macrophage ER stress response by AICAR

2016, Scientific Reports

Ricardo Capelo, Christoph Lehmann, Khalil Ahmad, Ryan Snodgrass, Olaf Diehl, Julia Ringleb, Nicolas Flamand, Andreas Weigert, Holger Stark, Dieter Steinhilber, Astrid Stefanie Kahnt

Cellular analysis of the histamine H4 receptor in human myeloid cells

2016, Biochemical Pharmacology

Rene Blöcher, Christina Lamers, Sandra K Wittmann, Olaf Diehl, Thomas Hanke, Daniel Merk, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Astrid Stefanie Kahnt, Eugen Proschak

Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

2016, Medicinal Chemistry Communications

Christine V. Möser, Markus Meissner, Kathrin Laarmann, Katrin Olbrich, Tanya S King-Himmelreich, Miriam C. Wolters, Gerd Geisslinger, Ellen Niederberger

The protein kinase IKKepsilon contributes to tumour growth and tumour pain in a melanoma model

2016, Biochemical Pharmacology

Nicole Mangels, Khader Awwad, Annika Wettenmanna, Laila Romagueira Bichara Dos Santos, Timo Frömel, Ingrid Fleming

The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity

2016, Prostaglandins & other lipid mediators

Julia Barthelmes, Nadja Tafferner, Jennifer Kurz, Natasja de Bruin, Michael J. Parnham, Gerd Geisslinger, Susanne Schiffmann

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

2016, Journal of visualized experiments

Peter Müller, Marie Messmer, Monika Bayer, Josef Pfeilschifter, Edith Hintermann, Urs Christen

Non-alcoholic fatty liver disease (NAFLD) potentiates autoimmune hepatitis in the CYP2D6 mouse model

2016, Journal of autoimmunity

Jörn Lötsch, Violeta Dimova, Alfred Ultsch, Isabel Lieb, Michael Zimmermann, Gerd Geisslinger, Bruno Oertel

A small yet comprehensive subset of human experimental pain models emerging from correlation analysis with a clinical quantitative sensory testing protocol in healthy subjects

2016, European Journal of Pain

Florian Ottenlinger, Anja Schwiebs, Kathrin Pfarr, Annika Wagner, Sophia Gruner, Christoph Mayer, Josef Pfeilschifter, Heinfried H. Radeke

Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-gamma production in CD8 lymphocytes

2016, European journal of immunology

Natasja de Bruin, Katja Schmitz, Susanne Schiffmann, Nadja Tafferner, Mike Schmidt, Holger Jordan, Annett Haussler, Irmgard Tegeder, Gerd Geisslinger, Michael J. Parnham

Multiple rodent models and behavioral measures reveal unexpected responses to FTY720 and DMF in experimental autoimmune encephalomyelitis

2016, Behavioural brain research

Christina Dillmann, Christian Ringel, Julia Ringleb, Javier Mora, Catherine Olesch, Annika Fink, Edward Roberts, Bernhard Brüne, Andreas Weigert

S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells

2016, Journal of immunology

Felix Friedländer, Ferdinand Bohmann, Max Brunkhorst, Ju-Hee Chae, Kavi Devraj, Yvette Kohler, Peter Kraft, Hannah Kuhn, Alexandra Lucaciu, Sebastian Luger, Waltraud Pfeilschifter, Rebecca Sadler, Arthur Liesz, Karoline Scholtyschik, Leonie Stolz, Rajkumar Vutukuri, Robert Brunkhorst

Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach

2016, Journal of Cerebral Blood Flow & Metabolism

Stefanie Hauck, Kerstin Hiesinger, Sabrina Khageh Hosseini, Janosch Achenbach, Ricardo M. Biondi, Eugen Proschak, Martin Zörnig, Dalibor Odadzic

Pyrazolo[1,5a]pyrimidines as a new class of FUSE binding protein 1 (FUBP1) inhibitors

2016, Bioorganic & Medicinal Chemistry

Claudia Knothe, Bruno Oertel, Alfred Ultsch, Mattias Kettner, Peter Harald Schmidt, Cora Wunder, Stefan W. Toennes, Gerd Geisslinger, Jörn Lötsch

Pharmacoepigenetics of the role of DNA methylation in mu-opioid receptor expression in different human brain regions

2016, Epigenomics

Simon Kretschmer, Stefano Woltersdorf, Dominik Vogt, Felix F. Lillich, Michael Rühl, Michael Karas, Isabelle Maucher, Jessica Roos, Ann-Kathrin Häfner, Astrid Kaiser, Mario Wurglics, Manfred Schubert-Zsilavecz, Carlo Angioni, Gerd Geisslinger, Holger Stark, Dieter Steinhilber, Bettina Hofmann

Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles

2016, Biochemical Pharmacology

Isabelle Maucher, Michael Rühl, Simon Kretschmer, Bettina Hofmann, Benjamin Kühn, Jasmin Fettel, Anja Vogel, Karsten T. Flügel, Georg Manolikakes, Nadine Hellmuth, Ann-Kathrin Häfner, Vahid Golghalyani, Ann-Katrin Ball, Matthias Piesche, Carmela Matrone, Gerd Geisslinger, Michael J. Parnham, Michael Karas, Dieter Steinhilber, Jessica Roos, Thorsten Maier

Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418

2016, Biochemical Pharmacology

Vassilios Myrianthopoulos, Nicola Gaboriaud-Kolar, Cynthia Tallant, Michelle-Lynn Hall, Stylianos Grigoriou, Peter Moore Brownlee, Oleg Fedorov, Catherine Rogers, David Heidenreich, Marek Wanior, Nikolaos Drosos, Nikitia Mexia, Pavel Savitsky, Tina Bagratuni, Efstathios Kastritis, Evangelos Terpos, Panagis Filippakopoulos, Susanne Müller, Alexios-Leandros Skaltsounis, Jessica Ann Downs, Stefan Knapp, Emmanuel Mikros

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

2016, Journal of Medicinal Chemistry

Florian Ottenlinger, Christoph Mayer, Nerea Ferreiros, Yannick Schreiber, Anja Schwiebs, Katrin Schmidt, Hanns Ackermann, Josef Pfeilschifter, Heinfried H. Radeke

Interferon-Beta Increases Plasma Ceramides of Specific Chain Length in Multiple Sclerosis Patients, Unlike Fingolimod or Natalizumab

2016, Frontiers in Pharmacology

Jessica Roos, Benjamin Kühn, Jasmin Fettel, Isabelle Maucher, Martin Ruthard, Astrid Stefanie Kahnt, Thomas Vorup-Jensen, Carmela Matrone, Dieter Steinhilber, Thorsten Maier

Role of Lipoxygenases in Pathogenesis of Cance

2016, Progress in Inflammation Research

Claudia Knothe, Alexandra Doehring, Alfred Ultsch, Jörn Lötsch

Methadone induces hypermethylation of human DNA

2016, Epigenomics

Katja Schmitz, Nicole Mangels, Annett Haussler, Nerea Ferreiros, Ingrid Fleming, Irmgard Tegeder

Pro-inflammatory obesity in aged cannabinoid-2 receptor-deficient mice

2016, International Journal of Obesity

Simon Kretschmer, Stefano Woltersdorf, Carmen Rödl, Dominik Vogt, Ann-Kathrin Häfner, Dieter Steinhilber, Holger Stark, Bettina Hofmann

Development of novel aminothiazole-comprising 5-LO inhibitors

2016, Future medicinal chemistry

Anika Berner, Malte Bachmann, Christine Bender, Josef Pfeilschifter, Urs Christen, Heiko Mühl

Though Active on RINm5F Insulinoma Cells and Cultured Pancreatic Islets, Recombinant IL-22 Fails to Modulate Cytotoxicity and Disease in a Protocol of Streptozotocin-Induced Experimental Diabetes

2016, Frontiers in pharmacology

Nadja Tafferner, Julia Barthelmes, Max Eberle, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Christoph Mayer, Christian Förch, Gerd Geisslinger, Michael J. Parnham, Susanne Schiffmann

Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE

2016, European journal of immunology

Rene Blöcher, Christina Lamers, Sandra K Wittmann, Daniel Merk, Markus Hartmann, Lilia Weizel, Olaf Diehl, Astrid Brüggerhoff, Marcel Boss, Astrid Kaiser, Tim Schader, Tamara Göbel, Manuel Grundmann, Carlo Angioni, Jan Heering, Gerd Geisslinger, Mario Wurglics, Evi Kostenis, Bernhard Brüne, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Astrid Stefanie Kahnt, Eugen Proschak

N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators

2016, Journal of medicinal chemistry

Ryan Snodgrass, Marcel Boss, Ekaterina Zezina, Andreas Weigert, Nathalie Dehne, Ingrid Fleming, Bernhard Brüne, Dmitry Namgaladze

Hypoxia Potentiates Palmitate-induced Pro-inflammatory Activation of Primary Human Macrophages

2016, The Journal of biological chemistry

Carmen Walter, Claudia Knothe, Jörn Lötsch

Abuse-Deterrent Opioid Formulations: Pharmacokinetic and Pharmacodynamic Considerations

2016, Clinical pharmacokinetics

Jessica Roos, Sabine Grösch, Oliver Werz, Peter Schröder, Slava Ziegler, Simone Fulda, Patrick Paulus, Anja Urbschat, Benjamin Kühn, Isabelle Maucher, Jasmin Fettel, Thomas Vorup-Jensen, Matthias Piesche, Carmela Matrone, Dieter Steinhilber, Michael J. Parnham, Thorsten Maier

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

2016, Pharmacology & therapeutics

Christoph Lehmann, Julia Homann, Ann-Katrin Ball, Rene Blöcher, Thea K Kleinschmidt, Devaraj Basavarajappa, Nerea Ferreiros, Ann-Kathrin Häfner, Olof Radmark, Jesper Z Haeggstrom, Gerd Geisslinger, Michael J. Parnham, Dieter Steinhilber, Astrid Stefanie Kahnt

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

2015, FASEB Journal

Violeta Dimova, Jörn Lötsch, Kathrin Hühne, Andreas Winterpacht, Michael Heesen, Andreas Parthum, Peter G Weber, Roman Carbon, Norbert Griessinger, Reinhard Sittl, Stefan Lautenbacher

Association of genetic and psychological factors with persistent pain after cosmetic thoracic surgery

2015, Journal of pain research

Stanley Lasch, Peter Müller, Monika Bayer, Josef Pfeilschifter, Andrew D Luster, Edith Hintermann, Urs Christen

Anti-CD3/Anti-CXCL10 Antibody Combination Therapy Induces a Persistent Remission of Type 1 Diabetes in Two Mouse Models

2015, Diabetes

Tanya S King-Himmelreich, Christine V. Möser, Miriam C. Wolters, Katrin Olbrich, Gerd Geisslinger, Ellen Niederberger

Age-Dependent Changes in the Inflammatory Nociceptive Behavior of Mice

2015, International journal of molecular sciences

Jörn Lötsch, Claudia Knothe, Catharina Lippmann, Alfred Ultsch, Thomas Hummel, Carmen Walter

Olfactory drug effects approached from human-derived data

2015, Drug discovery today

Alfred Ultsch, Michael Thrun, Onno Hansen-Goos, Jörn Lötsch

Identification of Molecular Fingerprints in Human Heat Pain Thresholds by Use of an Interactive Mixture Model R Toolbox

2015, International journal of molecular sciences

Khader Awwad, Lei Shi, Nicole Mangels, Randa Abdel Malik, Nina Zippel, Beate Fisslthaler, Johannes A Eble, Josef Pfeilschifter, Rudiger Popp, Ingrid Fleming

Role of secreted modular calcium-binding protein 1 (SMOC1) in transforming growth factor beta signalling and angiogenesis

2015, Cardiovascular Research

Max Eberle, Philipp Ebel, Christoph Mayer, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Christian Förch, Anika Männer de Bazo, Sabine Grösch, Gerd Geisslinger, Klaus Willecke, Susanne Schiffmann, Johannes A Eble

Exacerbation of experimental autoimmune encephalomyelitis in ceramide synthase 6 knockout mice is associated with enhanced activation/migration of neutrophils

2015, Immunology and cell biology

Daniel Flesch, Manfred Schubert-Zsilavecz

Synthesis of imidazo[1,2-a]pyridines in a sequential one-pot Groebke-Blackburn modification using 2-aminopyridines, aldehydes and amines

2015, Die Pharmazie

Khalil Ahmad, Bastian Scholz, Ricardo Capelo, Ilona Schweighofer, Astrid Stefanie Kahnt, Rolf Marschalek, Dieter Steinhilber

AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3

2015, Oncotarget

Katharina Syhr, Meike Boosen, Stephan Hohmann, Sebastian Longen, Yvette Kohler, Josef Pfeilschifter, Karl-Friedrich Beck, Gerd Geisslinger, Achim Schmidtko, Wiebke Kallenborn-Gerhardt

The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain

2015, Brain research

Susanne Beyer, Aline Moosmann, Astrid Stefanie Kahnt, Thomas Ulshöfer, Michael J. Parnham, Nerea Ferreiros, Sylvia Wagner, Matthias G. Wacker

Drug Release and Targeting: the Versatility of Polymethacrylate Nanoparticles for Peroral Administration Revealed by Using an Optimized In Vitro-Toolbox

2015, Pharmaceutical research

Anika Berner, Malte Bachmann, Josef Pfeilschifter, Peter Kraiczy, Heiko Mühl

Interferon-alpha curbs production of interleukin-22 by human peripheral blood mononuclear cells exposed to live Borrelia burgdorferi

2015, Journal of cellular and molecular medicine

Jörn Lötsch, Violeta Dimova, Bruno Oertel

Reply to "Can topical capsaicin induce a neuropathic pain?

2015, Pain

Carmen Walter, Violeta Dimova, Julia Bu, Michael J. Parnham, Bruno Oertel, Jörn Lötsch

Inverted Perceptual Judgment of Nociceptive Stimuli at Threshold Level following Inconsistent Cues

2015, PLoS One

Katharina Syhr, Bruno Oertel, Gerd Geisslinger

Drug interactions in pain therapy

2015, Schmerz

Li Xie, Susanne Beyer, Vitali Vogel, Matthias G. Wacker

Assessing the drug release from nanoparticles: Overcoming the shortcomings of dialysis by using novel optical techniques and a mathematical model

2015, International journal of pharmaceutics

Marcel Boss, Marina Kemmerer, Bernhard Brüne, Dmitry Namgaladze

FABP4 inhibition suppresses PPARgamma activity and VLDL-induced foam cell formation in IL-4-polarized human macrophages

2015, Atherosclerosis

Annika Wagner, Michaela Köhm, A. Nordin, E. Svenungsson, Josef Pfeilschifter, Heinfried H. Radeke

Increased Serum Levels of the IL-33 Neutralizing sST2 in Limited Cutaneous Systemic Sclerosis

2015, Scandinavian journal of immunology

Violeta Dimova, Bruno Oertel, Gulden Kabakci, Michael Zimmermann, Hanneke Hermens, Stefan Lautenbacher, Alfred Ultsch, Jörn Lötsch

A more pessimistic life orientation is associated with experimental inducibility of a neuropathy-like pain pattern in healthy individuals

2015, The journal of pain

Tanya S King-Himmelreich, Otto Quintus Russe, Christine V. Möser, Nerea Ferreiros, Katharina Kynast, Claudia Knothe, Katrin Olbrich, Gerd Geisslinger

AMP-activated protein kinase is activated by non-steroidal anti-inflammatory drugs

2015, European journal of pharmacology

Christina Dillmann, Javier Mora, Catherine Olesch, Bernhard Brüne, Andreas Weigert

S1PR4 is required for plasmacytoid dendritic cell differentiation

2015, Biological chemistry

Christine V. Möser, Heike Stephan, Katharina Altenrath, Katharina Kynast, Otto Quintus Russe, Katrin Olbrich, Gerd Geisslinger, Ellen Niederberger

TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-kappaB dependent genes

2015, Journal of neuroinflammation

Jörn Lötsch, Violeta Dimova, Isabel Lieb, Michael Zimmermann, Bruno Oertel, Alfred Ultsch

Multimodal distribution of human cold pain thresholds

2015, PLoS One

Bianca Gilbert, Khalil Ahmad, Jessica Roos, Christoph Lehmann, Tomohiro Chiba, Sandra Ulrich-Rückert, Leonie Smeenk, Simon van Heeringen, Thorsten Maier, Bernd Groner, Dieter Steinhilber

5-Lipoxygenase is a direct p53 target gene in humans

2015, Biochimica et Biophysica Acta

Christoph Mayer, Nadja Tafferner, Julia Barthelmes, Max Eberle, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Natasja de Bruin, Gerd Geisslinger, Christian Förch, Michael J. Parnham, Susanne Schiffmann

Different pathophysiological relevance of branched fatty acid metabolism in mice and men: alpha-methylacyl-CoA racemase regulates the T cell response only in experimental autoimmune encephalomyelitis but not in multiple sclerosis

2015, Multiple Sclerosis Journal

Christoph Mayer, Anika Männer de Bazo, Christian Förch, Max Eberle, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Thomas Ulshöfer, Marina Henke, Sabine Grösch, Gerd Geisslinger, Klaus Willecke, Susanne Schiffmann

Ceramide synthase6 / C16-ceramides mediate anti-inflammatory effects during the development of EAE and MS possibly by suppressing the migration and by deactivation of neutrophils: a new target for anti-inflammatory therapy in MS?

2015, Multiple Sclerosis Journal

Daniel Flesch, Matthias Gabler, Andreas Lill, Roberto Carrasco Gomez, Ramona Steri, Gisbert Schneider, Holger Stark, Manfred Schubert-Zsilavecz, Daniel Merk

Fragmentation of GW4064 led to a highly potent partial farnesoid X receptor agonist with improved drug-like properties

2015, Bioorganic & medicinal chemistry

Susanne Beyer, Li Xie, Susanna Grafe, Kerstin Dietrich, Arno Wiehe, Volker Albrecht, Werner Mantele, Matthias G. Wacker

Bridging laboratory and large scale production: preparation and in vitro-evaluation of photosensitizer-loaded nanocarrier devices for targeted drug delivery

2015, Pharmaceutical research

Julia Barthelmes, Anika Männer de Bazo, Yael Pewzner-Jung, Katja Schmitz, Christoph Mayer, Christian Förch, Max Eberle, Nadja Tafferner, Nerea Ferreiros, Marina Henke, Gerd Geisslinger, Anthony Futerman, Sabine Grösch, Susanne Schiffmann

Lack of ceramide synthase 2 suppresses the development of experimental autoimmune encephalomyelitis by impairing the migratory capacity of neutrophils

2015, Brain, behavior, and immunity

Catherine Olesch, Weixiao Sha, Carlo Angioni, Lisa Sha, Elias Acaf, Paola Patrignani, Per-Johan Jakobsson, Heinfried H. Radeke, Sabine Grösch, Gerd Geisslinger, Andreas von Knethen, Andreas Weigert, Bernhard Brüne

MPGES-1-derived PGE2 suppresses CD80 expression on tumor-associated phagocytes to inhibit anti-tumor immune responses in breast cancer

2015, Oncotarget

Katja Schmitz, Julia Barthelmes, Leonie Stolz, Susanne Beyer, Olaf Diehl, Irmgard Tegeder

"Disease modifying nutricals" for multiple sclerosis

2015, Pharmacology & therapeutics

Tilo Knape, Daniel Flesch, Laura Kuchler, Lisa Sha, Annika K Giegerich, Sandra Labocha, Mario Wurglics, Manfred Schubert-Zsilavecz, Eugen Proschak, Bernhard Brüne, Michael J. Parnham, Andreas von Knethen

Identification and characterisation of a prototype for a new class of competitive PPARgamma antagonists

2015, European journal of pharmacology

Jörn Lötsch, Violeta Dimova, Hanneke Hermens, Michael Zimmermann, Gerd Geisslinger, Bruno Oertel, Alfred Ultsch

Pattern of neuropathic pain induced by topical capsaicin application in healthy subjects

2015, Pain

Lisa Sha, Weixiao Sha, Laura Kuchler, Andreas Daiber, Annika K Giegerich, Andreas Weigert, Tilo Knape, Ryan Snodgrass, Katrin Schröder, Ralf Brandes, Bernhard Brüne, Andreas von Knethen

Loss of Nrf2 in bone marrow-derived macrophages impairs antigen-driven CD8(+) T cell function by limiting GSH and Cys availability

2015, Free radical biology & medicine

Karl-Friedrich Beck, Johannes Euler, Florian Eisel, Martina Beck, Yvette Kohler, Lisa Sha, Andreas von Knethen, Sebastian Longen, Josef Pfeilschifter

Cytokines induce protein kinase A-mediated signalling by a redox-dependent mechanism in rat renal mesangial cells

2015, Biochemical pharmacology

Daniel Moser, Sandra K Wittmann, Jan Krämer, Rene Blöcher, Janosch Achenbach, Denys Pogoryelov, Eugen Proschak

PENG: a neural gas-based approach for pharmacophore elucidation. method design, validation, and virtual screening for novel ligands of LTA4H

2015, Journal of chemical information and modeling

Daniel Flesch, Julia Ness, Christina Lamers, Friederike Dehm, Sven Popella, Isabella Ogorek, Martina Hieke, Gerd Dannhardt, Oliver Werz, Sascha Weggen, Manfred Schubert-Zsilavecz

SAR-studies of gamma-secretase modulators with PPARgamma-agonistic and 5-lipoxygenase-inhibitory activity for Alzheimer's disease

2015, Bioorganic & medicinal chemistry letters

Yasmin Moran-Auth, Marissa Penna-Martinez, Klaus Badenhoop

VDR FokI polymorphism is associated with a reduced T-helper cell population under vitamin D stimulation in type 1 diabetes patients

2015, The Journal of steroid biochemistry and molecular biology

Andreas von Knethen, Lisa Sha, Tilo Knape, Laura Kuchler, Annika K Giegerich, Martin Schulz, Ingeborg Hauser, Bernhard Brüne

Activation of the peroxisome proliferator-activated receptor gamma counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells

2015, Journal of Molecular Medicine

Klaus Badenhoop

Genetics: Vitamin D and type 2 diabetes mellitus - hype or hope?

2015, Nature reviews - Endocrinology

Laura Kuchler, Annika K Giegerich, Lisa Sha, Tilo Knape, Michael Wong, Katrin Schröder, Ralf Brandes, Heinrich Heide, Ilka Wittig, Bernhard Brüne, Andreas von Knethen

SYNCRIP-Dependent Nox2 mRNA Destabilization Impairs ROS Formation in M2-Polarized Macrophages

2014, Antioxidants & redox signaling

Max Eberle, Philipp Ebel, Marthe-Susanna Wegner, Julia Barthelmes, Nadja Tafferner, Nerea Ferreiros, Kerstin Birod, Yannick Schreiber, Gurumoorthy Krishnamoorthy, Klaus Willecke, Gerd Geisslinger, Sabine Grösch, Susanne Schiffmann

Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent

2014, Biochemical pharmacology

Annika K Giegerich, Laura Kuchler, Lisa Sha, Tilo Knape, Heinrich Heide, Ilka Wittig, Christian Behrends, Bernhard Brüne, Andreas von Knethen

Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression

2014, Autophagy

Jana Lorenz, Wiebke Kallenborn-Gerhardt, Ruirui Lu, Katharina Syhr, Philip Eaton, Gerd Geisslinger, Achim Schmidtko

Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury

2014, Antioxid Redox Signal

Wiebke Kallenborn-Gerhardt, Stephan Hohmann, Katharina Syhr, Katrin Schröder, Marco Sisignano, Andreas Weigert, Jana Lorenz, Ruirui Lu, Bernhard Brüne, Ralf Brandes, Gerd Geisslinger, Achim Schmidtko

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity

2014, Pain

Jessica Roos, Claudia Oancea, Maria Heinssmann, Dilawar Khan, Hannelore Held, Astrid Stefanie Kahnt, Ricardo Capelo, Estel la Buscato, Eugen Proschak, Elena Puccetti, Dieter Steinhilber, Ingrid Fleming, Thorsten Maier, Martin Ruthard

5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia

2014, Cancer research

Katja Schmitz, Natasja de Bruin, Philipp Bishay, Julia Barthelmes, Annett Haussler, Christine Altmann, Nerea Ferreiros, Jörn Lötsch, Alfred Ultsch, Michael J. Parnham, Gerd Geisslinger, Irmgard Tegeder

R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice

2014, EMBO molecular medicine

Katharina Syhr, Wiebke Kallenborn-Gerhardt, Ruirui Lu, Katrin Olbrich, Katja Schmitz, Julia Barthelmes, Nerea Ferreiros, Gerd Geisslinger, Ellen Niederberger, Achim Schmidtko

Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice

2014, harmacology, biochemistry, and behavior

Khader Awwad, Svenja Steinbrink, Timo Frömel, Nicole Mangels, Johann Isaak, Ann-Kathrin Häfner, Jessica Roos, Bettina Hofmann, Heinrich Heide, Gerd Geisslinger, Dieter Steinhilber, Bruce Freeman, Thorsten Maier, Ingrid Fleming

Electrophilic Fatty Acid Species Inhibit 5-Lipoxygenase and Attenuate Sepsis-Induced Pulmonary Inflammation

2014, Antioxidants & redox signaling

Daniel Flesch, Manfred Schubert-Zsilavecz

Phosphodiesterasen - Attraktive Ziele für Arzneistoffe

2014, Pharmazeutische Zeitung

Julia Homann, Christoph Lehmann, Astrid Stefanie Kahnt, Dieter Steinhilber, Michael J. Parnham, Gerd Geisslinger, Nerea Ferreiros

Chiral chromatography-tandem mass spectrometry applied to the determination of pro-resolving lipid mediators

2014, Journal of Chromatography A

Otto Quintus Russe, Christine V. Möser, Katharina Kynast, Tanya S King-Himmelreich, Katrin Olbrich, Sabine Grösch, Gerd Geisslinger, Ellen Niederberger

LPS inhibits caspase 3-dependent apoptosis in RAW264.7 macrophages induced by the AMPK activator AICAR

2014, Biochemical and biophysical research communications

Sebastian Sailler, Katja Schmitz, Elke Jäger, Nerea Ferreiros, Sabine Wicker, Katja Zschiebsch, Geethanjali Pickert, Gerd Geisslinger, Carmen Walter, Irmgard Tegeder, Jörn Lötsch

Regulation of circulating endocannabinoids associated with cancer and metastasis in mice and humans

2014, Oncoscience

Michael Schütz, Bruno Oertel, Dirk Heimann, Alexandra Doehring, Carmen Walter, Violeta Dimova, Gerd Geisslinger, Jörn Lötsch

Consequences of a human TRPA1 genetic variant on the perception of nociceptive and olfactory stimuli

2014, PLoS One

Daniel Merk, Matthias Gabler, Roberto Carrasco Gomez, Daniel Flesch, Thomas Hanke, Astrid Kaiser, Christina Lamers, Oliver Werz, Gisbert Schneider, Manfred Schubert-Zsilavecz

Anthranilic acid derivatives as novel ligands for farnesoid X receptor (FXR)

2014, Bioorganic & medicinal chemistry

Susanne Schiffmann, Andreas Weigert, Julia Barthelmes, Max Eberle, Kerstin Birod, Annett Haussler, Nerea Ferreiros, Yannick Schreiber, Manuel Grez, Weichand Benjamin Benjamin, Bernhard Brüne, Waltraud Pfeilschifter, Rolf Nüsing, Ellen Niederberger, Sabine Grösch, Klaus Scholich, Gerd Geisslinger

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis

2014, Biochemical pharmacology

Nathalie Dehne, Silke Essler, Theresa Geis, Tobias Schmid, Bernhard Brüne

IL-4 reduces the proangiogenic capacity of macrophages by down-regulating HIF-1alpha translation

2014, Journal of leukocyte biology

Claudia Goettsch, Andrea Babelova, Olivia Trummer, Reinhold Erben, Martina Rauner, Norbert Weissmann, Valeska Helfinger, Sebastian Benkhoff, Marian Kampschulte, Barbara Obermayer-Pietsch, Lorenz Hofbauer, Ralf Brandes, Katrin Schröder

NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis

2013, The Journal of clinical investigation

Katja Schmitz, Geethanjali Pickert, Nina Wijnvoord Wijnvoord, Annett Haussler, Irmgard Tegeder

Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia

2013, Brain, behavior, and immunity

Susanne Schiffmann, Kerstin Birod, Julia Barthelmes, Max Eberle, Marthe-Susanna Wegner, Ruth Wanger, Daniela Hartmann, Nerea Ferreiros, Gerd Geisslinger, Sabine Grösch

Ceramide metabolism in mouse tissue

2013, The international journal of biochemistry & cell biology

Dominik Bergis, Valentin Kassis, Annika Wagner, Verena Koeberle, Albrecht Piiper, Bernd Kronenberger, Stefan Zeuzem, Oliver Waidmann, Heinfried H. Radeke

High Serum Levels of the Interleukin-33 Receptor Soluble ST2 as a Negative Prognostic Factor in Hepatocellular Carcinoma

2013, Translational oncology

Astrid Stefanie Kahnt, Florian Rörsch, Olaf Diehl, Bettina Hofmann, Christoph Lehmann, Svenja Steinbrink, Carlo Angioni, Gerd Geisslinger, Sabine Grösch, Thorsten Maier

Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE synthesis by inhibiting mPGES-1 activity

2013, Biochemical pharmacology

Janosch Achenbach, Franca-Maria Klingler, Rene Blöcher, Daniel Moser, Ann-Kathrin Häfner, Carmen Rödl, Simon Kretschmer, Björn Krüger, Frank Lohr, Holger Stark, Bettina Hofmann, Dieter Steinhilber, Eugen Proschak

Exploring the chemical space of multitarget ligands using aligned self-organizing maps

2013, ACS Medicinal Chemistry Letters

Annemarie Schreeb, Maria Walter, Dalibor Odadzic, Johannes Stephan Schwed, Lilia Weizel, Holger Stark

Piperazine modification in 2,4,6-triaminopyrimidine derivatives as histamine H4 receptor ligands

2013, Die Pharmazie

Tilo Wuensch, Stephan Schulz, Sina Ullrich, Nicole Mangels, Tamara Stelzl, Isabel Rubio-Aliaga, Mathias Chamaillard, Gunnar Loh Loh, Dirk Haller, Hannelore Daniel

The peptide transporter PEPT1 is expressed in distal colon in rodents and humans and contributes to water absorption

2013, American journal of physiology. Gastrointestinal and liver physiology

Heiko Mühl, Patrick Scheiermann, Malte Bachmann, Lorena Hardle, Anika Berner, Josef Pfeilschifter

IL-22 in tissue protective therapy

2013, British journal of pharmacology

Wiebke Kallenborn-Gerhardt, Ruirui Lu, Katharina Syhr, Juliana Heidler, Harald von Melchner, Gerd Geisslinger, Thorsten Bangsow, Achim Schmidtko

Antioxidant activity of Sestrin 2 controls neuropathic pain after peripheral nerve injury

2013, Antioxidants & redox signaling

Alexander Visekruna, Josephine Ritter, Tatjana Scholz, Lucia Campos, Anna Guralnik, Lucia Poncette, Hartmann Raifer, Stefanie Hagner, Holger Garn, Valerie Staudt, Tobias Bopp, Sebastian Reuter, Christian Taube, Karin Loser, Magdalena Huber

Tc9 cells, a new subset of CD8+ T cells, support Th2-mediated airway inflammation

2013, European journal of immunology

Ken T Coppieters, Natalie Amirian, Philippe P Pagni, Carmen Baca Pagni, Anna Wiberg, Stanley Lasch, Edith Hintermann, Urs Christen, Matthias G von Herrath

Functional redundancy of CXCR3/CXCL10 signaling in the recruitment of diabetogenic CTL to pancreatic islets in a virally induced autoimmune diabetes model

2013, Diabetes

Yasmin Moran-Auth, Marissa Penna-Martinez, Firouzeh Shoghi, Elisabeth Ramos-Lopez, Klaus Badenhoop

Vitamin D status and gene transcription in immune cells

2013, The Journal of steroid biochemistry and molecular biology

Christina Lamers, Daniel Flesch, Manfred Schubert-Zsilavecz, Daniel Merk

Novel prostaglandin receptor modulators: a patent review (2002 - 2012) - part I: non-EP receptor modulators

2013, Expert opinion on therapeutic patents

Daniel Flesch, Daniel Merk, Christina Lamers, Manfred Schubert-Zsilavecz

Novel prostaglandin receptor modulators--part II: EP receptor modulators; a patent review (2002 - 2012)

2013, Expert opinion on therapeutic patents

Daniel Flesch, Manfred Schubert-Zsilavecz

Orale Antidiabetika in der klinischen Entwicklung

2013, Pharmakon

Estel la Buscato, Rene Blöcher, Franca-Maria Klingler, Steffen Hahn, Dieter Steinhilber, Manfred Schubert-Zsilavecz, Eugen Proschak

Design and synthesis of dual modulators of soluble epoxide hydrolase and peroxisome proliferator-activated receptors

2012, Journal of medicinal chemistry

Andreas Weigert, Weichand Benjamin Benjamin, Divya Sekar, Weixiao Sha, Christina Dillmann, Javier Mora, Stephanie Ley, Silke Essler, Nathalie Dehne, Bernhard Brüne

HIF-1alpha is a negative regulator of plasmacytoid DC development in vitro and in vivo

2012, Blood

Michaela Jung, Andreas Weigert, Michaela Tausendschon, Javier Mora, Bilge Oren, Anna Sola, Georgina Hotter, Tatsushi Muta, Bernhard Brüne

Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth

2012, Molecular and cellular biology

Divya Sekar, Christina Dillmann, Bernhard Brüne, Edward Roberts, Andreas Weigert

Apoptotic tumor cells induce IL-27 release from human DCs to activate Treg cells that express CD69 and attenuate cytotoxicity

2012, European journal of immunology

Susanne Schiffmann, Nerea Ferreiros, Kerstin Birod, Max Eberle, Yannick Schreiber, Waltraud Pfeilschifter, Ulf Ziemann, Sandra Pierre, Klaus Scholich, Sabine Grösch, Gerd Geisslinger

Ceramide synthase 6 plays a critical role in the development of experimental autoimmune encephalomyelitis

2012, The Journal of Immunology

Jessica Hoppstädter, Britta Diesel, Lisa Sha, Tobias Schmid, Bernhard Brüne, Alexandra K Kiemer

Glucocorticoid-induced leucine zipper is downregulated in human alveolar macrophages upon Toll-like receptor activation

2012, European journal of immunology

Daniel Flesch, Manfred Schubert-Zsilavecz

Tumortherapeutika vor der Zulassung

2012, Pharmazeutische Zeitung

Tobias Schmid, Magdalena Bajer, Johanna Blees, Larissa Milke, Daniela Rubsamen, Kathrin Schulz, Andreas Weigert, Nancy Colburn, Bernhard Brüne

Inflammation-induced loss of Pdcd4 is mediated by phosphorylation-dependent degradation

2011, Carcinogenesis